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Tomojit Bhattacharjee

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Review Open access Oct 2026

Recent advances in scaffold-based KRASG12C inhibitors: SAR and biological evaluation insights.

Over the past decade, targeting Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations has shifted from being considered an undruggable target to becoming a realistic therapeutic strategy with the development of KRASG12C inhibitors. This mutation replaces glycine with cysteine at codon 12, thereby reducing the GTP...

Tomojit Bhattacharjee, Ankush Kumar, Thakur Gurjeet Singh et al. · 0 citations

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