Tomohiko Wakayama

Hypertensive stress rewires macrophage signaling in heart failure with preserved ejection fraction independent of obesity

Heart failure with preserved ejection fraction (HFpEF) remains a major unmet clinical challenge. Although obesity is common in many HFpEF cohorts from Europe and North America, three Japanese HFpEF cohorts identified hypertension and sympathetic overactivation, rather than obesity, as dominant features. To model thes...