SRSF2 P95H induces monocytic priming of human hematopoietic stem and progenitor cells
Mutations in the splicing factor SRSF2 are commonly found in healthy individuals with clonal hematopoiesis (CH), where they confer a high annual clonal growth rate and an elevated risk for MDS/AML transformation [ 1 ]. Accordingly, SRSF2 mutations frequently occur in patients with myelodysplastic neoplasms (MDS, 10-15%...
Johannes Foßelteder, Gabriel Pabst, Andrea Raicht et al.
· Leukemia · 0 citations