Tomio Matsumura

HER2 CAR-expressing iPSC-derived iNKT cells exhibit multifaceted immunomodulatory functions beyond direct tumor killing

Background Autologous chimeric antigen receptor (CAR)-T cell therapy exhibits remarkable clinical efficacy for hematologic malignancies; however, its efficacy against solid tumors is limited by the immunosuppressive tumor microenvironment and the lack of effective strategies to induce broader antitumor immunity. Invari...