Open access
Jul 2026
Genome-wide CRISPR Screening Reveals Cullin-1 as a Therapeutic Target Enhancing Efficacy of CD19-directed Immunotherapy
C Cullin-1 inhibition stabilizes CD19 surface expression, preventing its loss under immunotherapeutic pressure and improving the efficiency of CD19-targeting immunotherapies, thus arguing for potential incorporation of pevonedistat into novel combination therapies.
N. V. Gottumukkala, Tomáš Loja, M. Šmída
· bioRxiv · 0 citations