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Tom L. Flood

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#protein folding Open access Oct 2026

A modular constitutive single-plasmid platform for efficient production of a recombinant Strep A glycoconjugate vaccine

Production of glycoconjugate vaccines has long relied upon chemical methods which are highly complex and expensive, resulting in vaccines that are not widely affordable. Heterologous bioconjugation methods, such as Protein-Glycan Coupling Technology (PGCT), have emerged as a path to significantly cheaper manufactur...

Mark A. Harrison, Tom L. Flood, Mark Reglinski et al. · 0 citations
Open access Sep 2026

Development and evaluation of a dual-target glycoconjugate against Shigella sonnei

A novel, conserved Shigella protein can be utilised as an effective carrier for the S. sonnei O-antigen to generate a Shigella-specific glycoconjugate that elicits IgG responses to both carrier protein and S. sonnei O-antigen.

C. L. Hall, Tom L. Flood, S. Clare et al. · 0 citations

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