Author

Tingjun Hou

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Open access Jul 2026

IgGM2: An All-Atom Foundation Model for Adaptive Immune Receptor Design

IgGM2 follows a structure-to-design strategy: it first learns how immune receptors are positioned around fixed target structures, and then transfers this target-conditioned structural prior to CDR design, allowing frame-work geometry to adapt to designed CDRs without separate inverse folding or external sidechain packing.

Jian Ma, Fandi Wu, Lin Yao et al. · bioRxiv · 0 citations

Preprint Aug 2026

EpiBench: Can LLMs Understand Epitopes for Antibody Drug Discovery?

The results show that current LLMs capture partial epitope-related signals but remain limited in antibody-specific sequence grounding, long-context residue localization, and biologically grounded reasoning, so EpiBench provides a diagnostic testbed for measuring and improving sequence-aware biomedical LLMs toward reliable LLM-assisted antibody discovery.

Zirui Wang, Jiaqing Wang, Qinghan Wang et al. · 0 citations