Open access
Oct 2026
Distinct cellular dynamics following CD19 and CD7 CAR-T therapies revealed by high-dimensional CyTOF analysis and impact on clinical outcomes
Compared with CD19 CAR-T therapy, CD7 CAR-T therapy was characterized by reduced CD8+ CAR-T persistence, early exhaustion, and delayed immune reconstitution, correlating with increased infections and higher non-relapse mortality.
Zhi-Peng Zhou, Yi-Yang Ding, Zhuo-Jun Liu et al.
· Journal of Translational Int... · 0 citations