How conserved neural circuits are modified during mammalian evolution remains poorly understood. Here we combine cross-species single-cell transcriptomics, in situ validation, retinal physiology, and conditional genetics to identify a superorder-associated adrenergic module in the mammalian retina. We find that ADRB1,...
Fu-Sheng Tang, Miao-Miao Kong, Ya-Ru Luo et al.· bioRxiv· 0 citations
Investigation of the roles of Ythdf family m6A readers in RGC development and their neurite outgrowth reveals important roles of m6A readers in RGC and their neurite development, which may facilitate future fundamental research and translational applications.
Ting Zhang, Kezhong Zhang, Qinghai He et al.· Experimental Eye Research· 0 citations
It is shown that MERTK maintains RPE survival and phagocytosis via regulating the RhoA/ROCK/cofilin/F-actin axis and rescued the MERTK depletion-induced phagocytic dysfunction and apoptosis of HsRPE cells and rat RPE.
Lujia Feng, Ting Zhang, Yong Du et al.· Current Medicinal Chemistry· 0 citations
It is shown that the NAD+ precursor NMN protects against retinal degeneration by improving mitochondrial function in MERTK-associated models, offering potential therapeutic insights.
