Author

Ting-Ting Wu

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Review Open access Aug 2026

Unveiling the Immune Mechanisms of Hypertension With Single‐Cell Transcriptome‐Wide Mendelian Randomization

Immune dysregulation is closely implicated in hypertension pathogenesis, yet specific therapeutic targets are lacking. We integrated expression quantitative trait loci (eQTLs) for genes expressed in 14 immune cell subsets (OneK1K) with two‐sample Mendelian randomization (MR) and colocalization to provide evidence for c...

Yu-Kang Mao, Peng Li, Chen Cheng et al. · The FASEB Journal · 0 citations

Sep 2026

Revealing Causal Proteomic Signatures of Hypertension: Systematic Insights From Proteome-Wide Mendelian Randomization.

BACKGROUND Hypertension is a major cardiovascular risk factor with an incompletely understood cause. We aimed to unravel its proteomic landscape and investigate potential molecular mechanisms underlying its risk related to modifiable exposures. METHODS Leveraging protein quantitative trait loci from 3 biobank-scale s...

Yu-Kang Mao, Yu-Er Jiang, Ting-Ting Wu et al. · HYPERTENSION · 0 citations