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Author

Ting-Ting Wang

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Open access Sep 2026

Delineation of molecular subtypes based on pathway activation signatures reveals intrinsic tumor heterogeneity and pan-cancer shared features

Four distinct molecular subtypes are defined based on the pathway activation profiles of pan-cancer, with each subtype displaying unique features in pathway activation, clinical manifestations, treatment response, survival prognosis, immune microenvironment, and drug sensitivity.

Ren Xu, Xiao Xiao, Jing-Lin Yang et al. · 0 citations
Review Open access Sep 2026

Targeted protein degradation dismantles undruggable targets to reverse immune evasion and therapy resistance in cancer

This Review examines the molecular engineering principles of bifunctional degraders and summarizes clinical progress demonstrating synergy with immune checkpoint blockade and adoptive cell therapy, and discusses how catalytic protein elimination overcomes primary immune evasion and adaptive resistance driven by compens...

Fu-Rong Zhang, Qian-Heng Wang, Ming-Xuan Li et al. · 0 citations

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