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Author

Tin-Yu J. Hui

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Open access Sep 2026

A novel unbiased Linkage Disequilibrium estimator through Random Probing

The linkage disequilibrium (LD) or correlation of alleles at different loci is a fundamental statistic in population genetics. This work presents a new estimator for the standardised LD measure r2 between a pair of loci. The Random Probe (RP) estimator involves generating a set of random dummy loci, before calculating...

Tin-Yu J. Hui, Austin Burt · 0 citations
Open access Sep 2026

Accounting for pseudo-replication of Linkage Disequilibrium for contemporary Ne estimation

The Linkage Disequilibrium of unlinked loci can be used to estimate contemporary effective population size (Ne) of one to a few generations ago and is inflated by about 550 times due to pseudo-replication, highlighting the danger of not handling genetic correlation properly.

Tin-Yu J. Hui, Lai-Yin Zhou, A. Burt · 0 citations

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