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Author

Timothy S. Strutzenberg

2 papers indexed here

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Open access Mar 2025

Nucleosome Engagement Regulates RORγt Structure and Dynamics

RORγt is a key transcriptional regulator that supports protective pathogen clearance but also drives autoimmune disorders. Genetic studies have identified RORγt mutations that selectively protect from autoimmunity without compromising host defense. Herein, we describe the molecular principles governing how RORγt select...

Timothy S. Strutzenberg, Xian-Du Li, Matthew D. Mann et al. · 0 citations
Open access Aug 2026

Structure of an RNA polymerase ribozyme replication complex

The structure of such a polymerase ribozyme bound to RNA substrates comprising the template, primer, and nucleoside triphosphate (NTP) analog is presented, revealing how directed evolution shaped flanking elements around a highly conserved catalytic core derived from the ancestral class I ligase ribozyme.

Timothy S. Strutzenberg, David P. Horning, W. Cochrane et al. · 1 citation

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