Open access
Jul 2026
Mucosal boosting of chimpanzee adenovirus-vectored vaccine encoding SARS-CoV-2 RBD-heterodimer provides robust protection in mice
A chimpanzee adenovirus (AdC68)-vectored vaccine expressing the Delta-XBB receptor-binding domain (RBD)-dimer is constructed and comprehensively compared the immune responses induced by intramuscular injection, intranasal administration, or aerosol inhalation, revealing that aerosol inhalation provided significantly better protection, without detectable replicating virus in the nasal tissue.
Xue-Yuan Liu, Yaling An, Huixin Duan et al.
· mBio · 0 citations