Tian Zhang

CysLENS: Interpretable signatures of cysteine ligandability from enantiomeric chemoproteomics and protein language models

Large chemoproteomic screens using covalent fragments map compound–cysteine engagements across the proteome, however, identifying robust, recognition-driven interactions remains a challenge due to experimental variability and electrophile reactivity. Here, we present CysLENS (Cysteine Ligandability Evaluation through N...