Tian-Tong Tao

Multilevel ensemble for genome-wide prediction of cell-specific G-quadruplexes utilizing transformed sequences and enhanced chromatin accessibility with G4Beacon2.

G-quadruplexes (G4) are prevalent non-B DNA structures playing crucial biological roles in cells. Although experimental technologies for G4 identification in vitro and in vivo are advancing, computational prediction methods are increasingly preferred for their efficiency, convenience, and cost effectiveness. However, e...