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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Tianqi Wu

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3 papers indexed here

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Open access Sep 2026

Conserved C-terminal residues adjacent to the canonical PDX1 homeodomain are required for chromatin occupancy and pancreas development.

Essential roles for the PDX1 transcription factor in pancreatic development and β-cell function are well-known, yet the structure-function relationships of domains within its C-terminus remain incompletely defined. We identified a focal intrinsically disordered region (IDR) spanning residues 207-223 of the Pdx1 C-termi...

Anthony S. Wokasch, Muhammad Shamoon, Courtney Campbell et al. · 0 citations
Open access Aug 2026

Enzymatic formation of a conserved isoaspartate in ribosomal protein uS11

Isoaspartate (isoAsp) formation is typically viewed as a “molecular clock” through nonenzymatic degradation of aspartate or asparagine during protein aging. Here we report a nearly universal enzymatic pathway for the formation of a conserved isoAsp in the bacterial ribosomal protein uS11. Proteome-wide protein-protein...

Yanqing Xue, Chandrima Majumdar, Salimat O. Sofela et al. · 0 citations
Open access Aug 2026

Proton-coupled alternating access in a versatile mycobacterial Spns drug transporter

Spns transporters are a mechanistically distinct branch of the major facilitator superfamily that regulate lipid transport, lysosomal homeostasis, immunity and disease, yet how the conserved Spns fold integrates protonation, substrate binding and alternating access to support chemically and directionally diverse transp...

Reza Dastvan, Samantha Gies, Kevin L. Jagessar et al. · 0 citations

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