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Open access Aug 2026

Benchmarking of pathology foundation models for assessing HER2 amplification and CEP17 polysomy in breast cancer

Accurate assessment of Human Epidermal Growth Factor Receptor 2 (HER2) amplification and Chromosome 17 (CEP17) copy number is critical for breast cancer treatment, yet diagnostically equivocal (IHC 2+) cases remain a clinical bottleneck. This study systematically benchmarks 14 feature encoders, including 12 Pathology...

Qing-Jie Lv, Xin Yu, Tao Wang et al. · 0 citations
Aug 2026

Achieving spatial multiomics diagonal integration from unaligned serial sections with DIME.

Learning integrated representations from spatial multiomics data is a fundamental challenge, particularly in the context of diagonal integration, where data are collected from serial tissue sections across distinct omics modalities. Existing methods typically rely on the assumption of feature intersection to construct...

Pengyu Sun, Tian Mou, Xin-Lei Huang et al. · 0 citations

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