Tian-Min Zhu

Stem cell senescence as a regenerative bottleneck in age-related skeletal degeneration: Mechanistic crosstalk and translational strategies

Skeletal degeneration is a major cause of pain, disability, fragility fracture, and loss of independence in aging populations. Although osteoporosis, osteoarthritis, and intervertebral disc degeneration are usually managed as anatomically separate disorders, they share a common regenerative failure: endogenous stem and...