Open access
Sep 2026
A core transcriptional regulatory circuitry controls super-enhancer-driven activation of LGR5 in colorectal cancer
The core transcriptional regulatory program governed by a small set of master transcription factors is pivotal for establishing context-specific cellular features. Here, we report the roles of master factor MYC in actively regulating cancer-type specific super-enhancer activity and orchestrating a super-enhancer-depend...
Min Ye, Shi-Lan Wang, Yong-Heng Chen et al.
· Nature Communications · 0 citations