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Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Author

Tianhua Zhai

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#diffusion models Review Open access Oct 2026

Estrogen and Alzheimer’s Disease: Neurobiology, Epigenetics, and AI-Driven Therapeutic Design

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder, and women are disproportionately affected. This review examines the evidence that estrogen signaling contributes to this disparity and asks what a molecularly targeted therapeutic would require. We first distinguish prevalence from incidence in the g...

Tian-Hua Zhai, Risa Garg, Pei-Ming Li et al. · 0 citations
Open access Jul 2026

Integrative single-nucleus multi-omics profiling identifies candidate regulators and signaling axes in Alzheimer’s disease lipid-processing microglia

Together, these results advance a described disease-associated microglial state into a reproducible, mechanistically framed regulatory model, providing candidate regulators, upstream ligands, and pharmacological probes for functional validation.

C. Zheng, Tianhua Zhai, Fang-Yuan Zhang et al. · 0 citations
Book Open access Jun 2026

UniPocket: Unified Ligand and Cryptic Pocket Prediction from Protein Language Model Embeddings

UniPocket is presented, a unified multitask framework for residue-level prediction of both ligand-binding and cryptic-pocket residues within a single shared-backbone architecture and achieves a macro ROC-AUC of 0.76.

Lening Zhao, Tianhua Zhai, Li Shen · 0 citations

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