Review
Open access
Sep 2026
Cuproptosis and anti-tumor immunity: bidirectional regulation, controversies, and translational prospects
Cuproptosis is a copper-dependent form of regulated cell death driven by copper binding to lipoylated tricarboxylic acid (TCA) cycle proteins. This interaction triggers aberrant protein aggregation, Fe-S cluster protein degradation, and mitochondrial proteotoxic stress, and its unique metabolic dependency distinguishes...
Xiang-Xiang Ren, Tian-Hao Xie, Xiao-Shi Jin et al.
· Frontiers in Immunology · 0 citations