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Open access Aug 2026

Identification of interleukin-11 as a comorbid risk factor for prostate cancer and Alzheimer’s disease using integrated bioinformatics and machine learning

Background Prostate cancer (PCa) and Alzheimer’s disease (AD) are age-related disorders with a complex epidemiological association and limited therapeutic options. Identifying shared molecular drivers may reveal new treatment targets. Objective To identify common transcriptomic signatures between PCa and AD and validat...

Meng-Xue Wang, Yan-Rong Qian, En-Yao Huang et al. · 0 citations
Open access Aug 2026

Linoleic acid metabolic reprogramming is linked to immunometabolic remodeling and post-transplant recurrence risk in hepatocellular carcinoma

Background Lipids serve as both metabolic substrates and signaling mediators that critically regulate immune cell fate, function, tolerance, and intercellular communication. In hepatocellular carcinoma (HCC), it remains unclear how intratumoral linoleic acid (LA) allocation between desaturation and oxidative catabolism...

Ruixin Zhang, Anhong Zhang, Tian Gao et al. · 0 citations

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