Author

Thorsten Bischler

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Open access Sep 2026

Intracellular Staphylococcus aureus triggers isolate-specific host transcriptional responses alongside TNF-R1 regulated cell fate decisions

Staphylococcus aureus (S. aureus) is an increasingly recognized intracellular pathogen, yet infection outcomes vary with bacterial isolate and host cell type. Many mechanisms underlying these differences remain poorly understood. This study investigated how distinct intracellular S. aureus isolates influence host signa...

Annika J. Walter, Thorsten Bischler, Marvin Jungblut et al. · Cell Communication and Signa... · 0 citations

Open access Sep 2026

Culture and gene expression profiling of Schwann cells from human sural nerve

Polyneuropathies (PNP) are diseases of the peripheral nervous system (PNS) whose pathophysiology remains poorly understood. Schwann cells (SC) are the principle glial cells in the PNS, and their dysfunction can lead to demyelination and secondary axonal degeneration, causing or exacerbating PNP. The study of SC can thu...

P. García-Fernández, Thorsten Bischler, A. Sodmann et al. · Communications Biology · 0 citations

Open access Jul 2026

The CRISPR/Cas-associated scaRNA modulates efeUOB expression and stress responses in Neisseria meningitidis

Abstract Neisseria meningitidis is a human-adapted commensal pathogen that must continuously balance nutrient acquisition with stress tolerance. Here, we identify a type II-C CRISPR/Cas-associated small RNA (scaRNA) as a posttranscriptional regulator of the efeUOB operon and oxidative stress responses. Using in vitro R...

Denise Pytlik, Milan Gerovac, Thorsten Bischler et al. · microLife · 0 citations