Sep 2026
Design, synthesis, and biological evaluation of novel dihydropyrimidinone imines as potent anticancer agents targeting AKT to induce cell cycle arrest and apoptosis in breast Cancer cells.
Findings indicate that compound 10 exerts efficient antineoplastic impact associated with the downregulation of the RAS/PI3K/AKT/GSK-3β pathway proteins.
M. Gerges, A. Noser, Eman G. Ibrahim et al.
· Bioorganic & Medicinal Chemi... · 0 citations