Author

Thomas Sauter

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Open access Aug 2026

Crosstalk between S-nitrosylation and glycation defines a metabolic vulnerability in liver and renal cancers

Metabolic reprogramming is a defining feature of cancer; however, how it contributes to therapeutic resistance remains incompletely understood. Here we show that loss of aldo-ketoreductase 1A1 (AKR1A1) in renal cell carcinoma (RCC) and hepatocellular carcinoma (HCC) disrupts terminal glycolytic flux and lactate product...

Chiara Pecorari, Mojca Bratina, Evelyn Gonzalez et al. · Nature Communications · 1 citation

Open access Jul 2026

WILDkCAT: extract, retrieve, and predict enzyme turnover numbers of constraint-based metabolic models

Abstract Summary Accurate enzyme turnover numbers are essential for building enzyme-constrained genome-scale metabolic models. However, collecting and curating these parameters remains a major bottleneck. Indeed, kcat values are scattered across multiple databases, reported under varying experimental conditions, and of...

Hugues Escoffier, Carole L. Linster, Thomas Sauter · Bioinformatics · 0 citations