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Author

Thomas D. Bannister

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Open access Aug 2026

Discovery of two novel small-molecule series with potent SARS-CoV-2 inhibition via putative nsp13 open-state trapping

The phenoxypropanol (PP) and bipiperidine (BPP) series stood out as the most promising SARS-CoV-2 antivirals, with integrated analysis of structure–activity relationships, physicochemical parameters, metabolic stability, and interdomain dynamics delineated structural optimization paths for both series.

Alma C. Castañeda-Leautaud, Thomas D. Bannister, Eunjung Kim et al. · 0 citations

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