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Author

Thomas Brück

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Open access Jul 2026

Fluorescence-Activated Cell Sorting Enables Rapid Screening of RNA Polymerase–Promoter Interaction in E. coli

A high-throughput strategy for rapid promoter identification using a two-plasmid screening platform in E. coli that substantially accelerates promoter characterization, thereby supporting improvements regarding mRNA manufacturing workflows.

Lilian Göldel, Ralph Krafczyk, Romina Rathberger et al. · 0 citations
Review Open access Jul 2026

Bridging Algorithms and Biocatalysis: Perspectives on AI-Supported Enzyme Engineering

Recent advances in AI-based computational enzyme design are presented, discussing the main challenges in the field and how a combination with classical physics-based methods could help overcome them.

Rosa Teijeiro-Juiz, Thomas B Brück, Bernhard Loll · 0 citations
Review Open access Jul 2026

Applications and limitations of AI tools in enzyme design

A comprehensive introduction and overview of several current artificial intelligence (AI)‐driven methods available for enzyme design, with a focus on reaction‐to‐sequence design, structure prediction, substrate scope prediction, engineering of stable variants, design of enzymes with non‐canonical amino acids, and de no...

Rosa Teijeiro-Juiz, Nina Egeler, Grzegorz Jamróg et al. · 2 citations

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