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Sponsored Artificial Intelligence: A Modern Approach, Global Edition Artificial Intelligence: A Modern Approach, Global Edition

Author

Thomas A. Desautels

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Open access Aug 2026

Unobserved Sequence Space Has Many Functional Proteins

It is determined that portions of protein sequence space, despite being unobserved in nature, contains many functional proteins that cannot be predicted accurately in silico, providing experimental support for the hypothesis that natural protein sequences explored by evolution represent a miniscule fraction of all possible functional sequences.

Nathan Diplock, Thomas A. Desautels, Riyaz Haque et al. · 0 citations

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