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Thomas A. Desautels

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Open access Sep 2026

Profiling the Efficacy of CR1- Monoclonal Antibody Series Against New World Arenaviruses

Junín virus (JUNV) is the causative agent of Argentine Hemorrhagic Fever (AHF) with the capacity for human-to-human transmission. AHF is endemic to Argentina and is prevented in at-risk populations with the regionally approved Candid#1 live attenuated vaccine (JUNV/C#1). However, there are barriers to US FDA (Fed...

Sharon Jan, Christopher A. Sumner, Grecia Sandoval et al. · 0 citations
Open access Aug 2026

Unobserved Sequence Space Has Many Functional Proteins

It is determined that portions of protein sequence space, despite being unobserved in nature, contains many functional proteins that cannot be predicted accurately in silico, providing experimental support for the hypothesis that natural protein sequences explored by evolution represent a miniscule fraction of all poss...

Nathan Diplock, Thomas A. Desautels, Riyaz Haque et al. · 0 citations

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