Author

Thierry Couffinhal

2 papers indexed here

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Open access

Discontinuation of statins for primary prevention of atherosclerotic cardiovascular disease in adults aged 75 years or older (SAGA/SITE): a multicentre, open-label, pragmatic, non-inferiority randomised trial.

BACKGROUND Statins are among the most widely used drugs; however, their benefits for primary prevention of atherosclerotic cardiovascular disease (ASCVD) in individuals aged 75 years or older without the disease remain uncertain. We aimed to assess the non-inferiority of statin cessation in terms of all-cause mortality...

F. Bonnet, P. Poulizac, Nicolas Rousselot et al. · The Lancet Healthy Longevity · 1 citation

Open access Sep 2026

Genetic Insights Into Protective Effects of GLP-1 Receptor Agonists on Stroke and Alzheimer Disease Across Ancestries

Background and Objectives Stroke and dementia are leading causes of death and disability worldwide, requiring enhanced preventive strategies. Glucagon-like peptide-1 receptor agonists (GLP-1RA), widely used for type 2 diabetes (T2D) and obesity, have demonstrated pleiotropic effects, including cardiovascular benefits,...

Ilana Caro-Châtelier, M. Sargurupremraj, Cheng-Ran Yang et al. · Neurology: Genetics · 1 citation