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Author

Thiago Moreira Pereira

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Open access Jul 2026

Structural and Biophysical Characterization of Aminobenzo[d]isothiazole 1,1-Dioxide SOS1 Ligands

Comparative analysis further delineates vector requirements for productive engagement of KRAS-facing regions, providing a structure-based framework for future optimization of aminobenzo[d]isothiazole 1,1-dioxide SOS1 ligands.

Thiago Moreira Pereira, Atilio Reyes Romero, M. van der Laan et al. · 0 citations
Review Open access Jul 2026

One Face, Three Solutions: Structural Convergence in PD-L1 Inhibition across Antibodies, Macrocycles, and Small Molecules

A comparative, structure-driven analysis of PD-L1 complexes deposited in the Protein Data Bank is presented and it is demonstrated that distinct inhibitory modalities converge on the same functional CC′FG hotspot region while employing fundamentally different neutralization mechanisms.

Imma Capriello, T. Moreira Pereira, Gustavo Barbosa Reis et al. · 0 citations

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