Author

Thi Thuc Uyen Phan

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Open access Oct 2026

Prostate Cancer Patient-Derived Organoids (PDOs) as Functional Avatars for Antisense Oligonucleotide (ASO)-Based Personalized Therapy.

Patient-derived tumor organoids (PDOs) closely preserve the cellular heterogeneity, histopathology, and molecular features of the original tumors, making them powerful preclinical models. Antisense oligonucleotides (ASOs) are an emerging class of precision medicines that modulate gene expression at the RNA level with h...

Thi Thom Tran, Thi Thuc Uyen Phan, M. Baboudjian et al. · Advanced Healthcare Material... · 0 citations

Open access Sep 2026

A novel 5-FU derivative chemotherapy: a promising pan-cancer treatment to improve antitumor efficacy and overcome therapy resistance

Management of advanced solid cancers remains challenging, particularly after the development of therapeutic resistance. Here, we synthesized a library of phosphonium-substituted 5-fluorouracil (5-FU) derivatives and evaluated their anticancer activity across multiple tumor models. Among fourteen compounds, EB-18 emer...

Quang Hieu Duong, E. Khusnutdinova, T. Le et al. · Journal of Experimental &amp... · 0 citations