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Author

Theresa A. Boyle

2 papers indexed here

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Sep 2026

KRAS-G12C inhibition-induced enrichment of MHC-Ihigh immune-active tumor cells directs immune-effector TME development to augment therapeutic efficacy.

Inhibition of KRASG12C (G12Ci) has shown promising clinical activity in several cancers; however, emergence of resistance is a major limitation to long-term benefit. It remains unknown how G12Ci impacts the tumor immune microenvironment and its association with resistance. We investigated the immune modulatory impact o...

Mohammed L. Ibrahim, Dana Foresman, Hong Zheng et al. · 0 citations
Review Sep 2026

Nongenetic Factors Associated With Onset and Severity of Hereditary Ataxia.

OBJECTIVES Spinocerebellar ataxias (SCAs) are rare neurodegenerative disorders that arise from genetic sequence variants causing progressive imbalance and motor incoordination. Few studies have investigated nongenetic correlates of patient variation in onset and severity of SCA6 and 27B. METHODS Participants with gen...

Hannah L. Casey, Maria Springall De Pablo, Theresa A. Boyle et al. · 0 citations

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