Author

Theodore M. Nelson

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Open access Oct 2026

Modulator Resolves Transcript-, Allele-, and Condition-associated RNA Modification Differences from Direct RNA Sequencing

Nanopore direct-RNA sequencing (DRS) reports RNA modifications on single molecules, but there is no comprehensive algorithm for processing, aligning, and differentiating base modifications across reads that are often 5′-truncated. Here we present Modulator, which assigns every read, truncated or not, to a “fragmentform...

Theodore M. Nelson, Michael Goneos, Caroline J. Aufgebauer et al. · bioRxiv · 0 citations

Aug 2026

An inflammatory bowel disease-linked lncRNA suppresses transcription factor T-BET expression in T cells to limit intestinal inflammation.

Among the tens of thousands of annotated long noncoding RNAs (lncRNAs) in the human genome, only a small fraction have been functionally characterized. Here, we show that a well-established inflammatory bowel disease (IBD) risk locus encoded a conserved lncRNA, lnc15 (2310015A10Rik/ENSMUSG00000097729), whose structure...

Ruxiao Yang-Fischer, A. Shearer, Jingyao Zhao et al. · Immunity · 0 citations