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Thanh Tran

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Open access Oct 2026

Molecular Mechanism of pH-Dependent Activation in Human Equilibrative Nucleoside Transporter 3.

Human equilibrative nucleoside transporter 3 (hENT3) is a lysosomal transporter whose activity is strictly dependent on an acidic lumenal environment. Mutations in hENT3 lead to H syndrome and other metabolic disorders, yet the structural basis for its pH-sensitive gating remains poorly defined. Using multi-replica con...

Thanh Tran, Jung-Hsin Lin · 0 citations

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