Development and In Vitro Evaluation of Near-Infrared Dye-Conjugated Pullulan-Based Nanogels for M2 Macrophage-Targeted pH-Responsive Theranostic Agents
Immunotherapy can reduce treatment-related side effects but shows limited efficacy in “cold tumors,” whose immunosuppressive tumor immune microenvironment is characterized by abundant M2 macrophages and poor T cell infiltration. Because biopsy-based qualitative assessment of the tumor microenvironment is invasive and c...