Open access
Sep 2026
The Human PNPLA3I148M Polymorphism Alters the Renal Kinome and Transporters to Cause Hyperfiltration and Hypertension
The patatin‐like phospholipase domain‐containing protein 3 (Pnpla3) I148M polymorphism is a well‐established genetic determinant of metabolic dysfunction‐associated steatotic liver disease (MASLD), and emerging evidence links it to chronic kidney disease (CKD) and cardiovascular disease (CVD). However, the mechanisms u...
Gertrude Arthur, Michael I. Adenawoola, Sally Wahba et al.
· FASEB bioAdvances · 0 citations