Tengku Anggia Fitri

Design and mechanistic evaluation of chalcone–quinoline–triazole hybrids as antifungal CYP51 inhibitors

Mechanistic investigations demonstrated that compound 7b markedly disrupted fungal sterol biosynthesis, as evidenced by significant ergosterol depletion, lanosterol accumulation, and a pronounced reduction in the ergosterol/lanosterol ratio across all tested Candida species.