SMS2 Inhibition Alleviates Endothelial Dysfunction and Atherosclerosis via Promoting NFE2L1 expression to Suppress Ferroptosis.
Sphingomyelin synthase 2 (SMS2) is a key enzyme in sphingomyelin synthesis and is implicated in atherosclerosis (AS). Both endothelial dysfunction (ED) and ferroptosis contribute to AS, but their relationship with SMS2 remains unclear. To explore this, we inhibited SMS2 with Ly93 and then performed RNA sequencing to as...