ABSTRACT Adjuvants can enhance the elicited immune responses to recombinant hemagglutinin (HA) proteins following intramuscular vaccination. In this study, computationally optimized broadly reactive antigen (COBRA) designed HA proteins were adjuvanted with the W805EC oil-in-water nanoemulsion (“NE01”) and used to vacci...
Matthew H. Thomas, Ted M. Ross· Human Vaccines & Immunothera...· 0 citations
Seasonal influenza vaccines provide variable protection against antigenically drifted influenza A (H1N1 and H3N2) and influenza B viruses. Broadly protective approaches using computationally optimized broadly reactive antigens (COBRAs) can enhance immunity against diverse strains. Bis-(3′,5′)-cyclic dimeric adenosine m...
Camila C. S. Caetano, David A. Prots, Matthew H. Thomas et al.· Frontiers in Immunology· 0 citations
This ex vivo primary ferret nasal epithelial cell and peripheral blood mononuclear cell co-culture model shows that signaling decoupling across the "epithelial-immune bridge" drives suboptimal IBV immunogenicity.
These findings demonstrate that COBRA HA encoding mRNA vaccines can effectively leverage immunological memory while expanding responses to conserved HA epitopes, supporting improved protection against antigenically drifted strains and represents a promising strategy for next-generation influenza vaccination.
James D. Allen, Jessica M. Medina, Camila Caetano et al.· bioRxiv· 0 citations
It is demonstrated that an integrated generation–selection strategy can enhance vaccine coverage across current and future A(H3N2) seasons and may be applicable to other influenza subtypes.
Victoria R. Howard, James D. Allen, Matthew H. Thomas et al.· bioRxiv· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
