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Author

Tatsuki Onishi

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Review Open access Sep 2026

The Hidden Cost of Reproducibility: Commercial Software Dependency in Published Research and the Version Accessibility Gap

The reproducibility crisis in science has prompted widespread efforts to improve data and code sharing. However, a critical yet underexplored barrier persists: dependency on commercial software whose specific versions are often inaccessible for replication. We conducted a cross-sectional study of 10,000 articles publis...

Tatsuki Onishi, Tatsuyoshi Ikenoue · 0 citations
Open access Sep 2026

Unconventional Molecular Descriptors for Blood-Brain Barrier Permeability Prediction: A Unified Model and Its Implications for Local Anesthetic Design, Micellar Formulation, and Chelation-Based Effect Modification.

BACKGROUND Predicting blood-brain barrier (BBB) permeability remains a central problem in central nervous system (CNS) drug design. Conventional rules such as Lipinski's rule of five and related CNS guidelines describe physicochemical boundaries but do not guarantee permeability. OBJECTIVE We examined how a set of mo...

Tatsuki Onishi · 0 citations

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