Author

Tatjana Kleele

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Open access Sep 2026

Misfolding of cystathionine beta-synthase impairs mitochondrial homeostasis and cellular bioenergetics.

Homocystinuria (HCU) is an inborn error of metabolism and a conformational disorder chiefly caused by the missense mutations in the cystathionine beta-synthase (CBS) gene. These mutations often cause CBS destabilization, misfolding and dysfunction resulting in CBS deficiency and pathological accumulation of homocystein...

Ela Mijatovic, T. M. Philipp, Karim Zuhra et al. · Free Radical Biology & Medic... · 0 citations

Open access Sep 2026

Comparative characterization of mitochondrial components across size-defined extracellular vesicle populations derived from HaCaT keratinocytes.

The transfer of mitochondrial cargo through extracellular vesicles (EVs) has been reported in several model systems and cell types, yet a detailed characterization of mitochondrial components across different EV populations remains limited. Here, we characterized the mitochondrial cargo of small EVs (sEVs) and large EV...

Finn Brigger, A. Kitanovic, Sébastien Meurant et al. · International journal of pha... · 0 citations

Open access Aug 2026

Mitochondrial profiling across macrophage states reveals inhibition of IL-4/IL-13 reprogramming by the integrated stress response

This work integrates transcriptomics with whole-cell and purified mitochondrial proteomics to profile lipopolysaccharide (LPS)/interferon-γ (IFN-γ)– and interleukin-4 (IL-4)/IL-13–stimulated macrophages and identifies mtDNA expression, intramitochondrial translation, and mitochondrial membrane potential as critical, dr...

Joan Blanco-Fernández, Miriam Lisci, Mads M. Foged et al. · Science Advances · 0 citations