Tasniqul Islam

Scoring close linker analogues in PROTAC ternary complexes: A matched-pose study of VHL-recruiting SHP2 degraders

Linker optimisation in targeted protein degradation remains largely empirical, and a computational method able to rank close analogues before synthesis would be valuable. Whether current methods can do so has not been tested against the smallest chemical difference that changes potency. Here two VHL-recruiting SHP2 deg...