Abstract Alzheimer’s disease (AD) affects over 55 million individuals worldwide, yet approved pharmacotherapies remain limited to symptomatic relief. Dual inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) offers a validated approach to restoring cholinergic tone. However, structurally differen...
Y. Khan, Mujeeb Ul Naeem, Syeda Farwa Naqvi et al.· Zeitschrift für Naturforschu...· 0 citations
Background: Urothelial carcinoma exhibits molecular heterogeneity, high recurrence, and progression rates, and is poorly diagnosed and treated. Transcriptomic and systems-biology analyses can detect dysregulated genes, signaling pathways, and interactions of immune cells. Proposed biomarkers, however, have not been val...
Shaza N. Alkhatib, A. Binsaleh, N. Al-Hoshani et al.· Biomedicines· 0 citations
This study presents a structurally optimized and validated multiepitope vaccine candidate against the emerging Batai orthobunyavirus, identifying a promising vaccine candidate for further investigation; however, its immunogenicity, safety, and protective efficacy before further vaccine development can be considered.
M. A. Alwaili, N. Al‐Hoshani, Huda A Alqahtani et al.· Pharmaceuticals· 0 citations
The results highlight the potential of the proposed multi-epitope construct as a promising vaccine candidate against HCMV, however, experimental validation is essential to confirm its immunogenicity, safety, and translational applicability.
O. P. Emmanuel, M. N. Y. Sandrine, Bilanda Danielle Claude et al.· Scientific Reports· 0 citations
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