Author

Tao Zhou

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Open access Oct 2026

Integrated network toxicology, transcriptomic, and Mendelian randomization analyses explore potential molecular links between acrylamide exposure and clear cell renal cell carcinoma

Acrylamide is a potential carcinogen widely encountered in occupational settings and heat-processed foods. However, the potential molecular relationships between acrylamide-associated targets and clear cell renal cell carcinoma remain poorly characterized. The toxicological characteristics of acrylamide were predicted...

Shu-Wen Deng, Shuang Wang, Zhi-Qiang Zeng et al. · Medicine · 0 citations

Open access Sep 2026

BDE-47 and male infertility: integrated network toxicology, single-cell transcriptomics, and in vitro evidence of GSTM1 downregulation and ferroptosis-related molecular remodeling in Leydig cells

BDE-47-related molecular evidence and human NOA-associated evidence showed molecular convergence around GSTM1 and ferroptosis-related molecular features in a Leydig-cell context, but this does not establish direct binding, GSTM1-mediated effects, ferroptotic cell death, or a causal relationship between BDE-47 exposure...

Xin-Yao Zhu, Shuang Wang, Tao Li et al. · Frontiers in Immunology · 0 citations

Open access Sep 2026

Integrative network toxicology analysis reveals mechanistic links between PFOA exposure and male reproductive dysfunction

To systematically investigate the molecular mechanisms linking perfluorooctanoic acid (PFOA) to male reproductive health outcomes within a network toxicology framework, and to compare shared pathways across erectile dysfunction (ED), male infertility, and testicular dysfunction. PFOA associated targets were identified...

Tao Zhou, Xin-Yu Zhang, Jing-Hong Yang et al. · Basic and Clinical Andrology · 0 citations