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Author

Tao Wen

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Sep 2026

A Progression-Associated Tumor-Reactive T-Cell Signature Predicts Immunotherapy Response and Reveals ICOS-High CD8 T-Cell Functional States in Head and Neck Squamous Cell Carcinoma.

Immune checkpoint blockade has improved outcomes for patients with head and neck squamous cell carcinoma (HNSCC), but reliable biomarkers for predicting therapeutic response remain limited. Tumor-reactive T-cell states are increasingly recognized as critical determinants of antitumor immunity; however, progression-asso...

Shao-Qian Zhang, Xiao-Tong Yan, Xi-Chen Dong et al. · 0 citations
Review Open access Jul 2026

Cancer stem cell plasticity: mechanisms, immune microenvironment crosstalk, and therapeutic implications

A particular focus on the bidirectional interplay between CSCs and the tumor immune microenvironment is focused on, which may provide a conceptual framework for the development of more rational combination strategies, although their clinical benefit remains to be validated.

Jingyu Tan, Tao Wen, Jian Liu et al. · 0 citations

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