ProMeta: Few-shot PROTAC-targeted degradation prediction across E3 ligases
ProMeta, a prototype-based graph neural network trained through episodic meta-learning on source-E3 tasks and evaluated on held-out target-E3 tasks through support-conditioned inference, is presented as a practical framework for cross-ligase few-shot prediction under the evaluated support/query protocols.
Yuansheng Liu, Yu-Fei Ye, Tao Tang et al.
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