ABSTRACT Chronic stress frequently occurs in patients with cancer, yet how stress is translated into pro‐metastatic programs remains unclear. Here, using chronic restraint stress (CRS) in male mice, we show that stress increases metastatic burden and reduces survival in lung metastasis and peritoneal dissemination mode...
Si-Cheng Zhao, Zhi-Yuan Song, Jing-Cheng Zhang et al.· Advancement of science· 0 citations
Gastric cancer metastasis and poor treatment responses are spatially heterogeneous; however, single-marker positivity, cellular enrichment, or simple colocalization alone is insufficient to establish a functionally meaningful spatial niche. Within this framework, “treatment resistance” encompasses primary nonresponse,...
Yi Huang, Jing-Cheng Zhang, Jiaheng Lou et al.· Cells· 0 citations
HJSS alleviates MNNG-induced CAG by attenuating inflammatory injury and promoting the recovery of gastric mucosal barrier-associated molecular features, supporting an inflammation–barrier mechanism underlying the action of HJSS in CAG.
Shuo Zhang, Shuya Zhang, Mengyi Wang et al.· Frontiers in Immunology· 0 citations
It is demonstrated that MCT4 drives HCC progression through two complementary mechanisms: enhancing MMP-mediated invasion and metastasis, and promoting immunosuppressive M2 macrophage polarization.
Kaiyuan Zhang, Xiaochen Ni, Chuhang Wang et al.· Frontiers in Immunology· 0 citations
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