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Tanya Nesterova

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Open access Oct 2026

Disentangling polymer confinement from specific-folding interactions reveals the drivers of Escherichia coli chromosome organization

Abstract The three-dimensional organization of the bacterial chromosome is critical for gene regulation. Chromosome conformation capture (Hi-C) has enabled genome-wide mapping of chromosomal folding, yet ensemble-averaged contact maps entangle biologically specific-folding interactions (SFIs) with nonspecific polymer c...

Pourya Delafrouz, Tanya Nesterova, Frances E. Harris et al. · 0 citations

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